專題演講活動

題    CCRL2 is prostate cancer cell stemness mediator that regulates the organ-specific cancer metastasis

講    者:宋賢穎 副教授

者單位:轉譯醫學博士學位學程

   20218 16

主辦單位:細胞治療與再生醫學研究中心

110/4/15 李彥樑 副總經理 Genomics and Big Data (10:00~12:00) 大安校區B203會議室

主講人:李彥樑 副總經理
講 題:Genomics and Big Data
時 間:110/4/15(四) 10:00~12:00
地 點:大安校區B203會議室
報名方式:
1.北醫教職員:
請先登入 http://goo.gl/p2qWP9
進入此頁面報名 https://reurl.cc/6yjaer
 
2. 學生、無法登入學習發展平台者:請直接前往會場即可
誠摯邀請本校教師與同仁們撥冗參與!
此為英文演講。(Language: English)

敬邀參加109年12月16日(W3) 轉譯學程專家演講 王志豪 助理教授

敬邀參加109年12月16日(W3) 轉譯學程專家演講

主講人:王志豪 助理教授

講 題:CRISPR engineered human brown like adipocytes ameliorate metabolic dysregulation in mice

時 間:109年12月16日(W3) 13:00~15:00

地 點:大安校區 B2 B203會議室

報名方式:

1.北醫教職員:

請先登入 https://reurl.cc/6lYkOO

進入此頁面報名

https://reurl.cc/gmlYqz

2.學生、無法登入學習發展平台者:請直接前往會場即可

誠摯邀請本校教師與同仁們撥冗參與!

Special Lecture

Speaker: Chih-Hao Wang (Assistant Professor)

Date :2020-12-16 (Wednesday)

Venue: B203, B2F, Daan campus

Time:13:00~15:00

Language:English

CRISPR-engineered human brown-like adipocytes ameliorate metabolic dysregulation in mice

Abstract

Brown and white fats play crucial roles in systemic energy homeostasis. Brown fat is specific for energy dissipation and has multilocular lipid droplets, while white fat is the main site for storing excess fuel containing unilocular lipid droplets. The activity and amount of brown fat are inversely correlated with body mass index in mammals, making brown fat an appealing target for anti-obesity therapies. Aiming for transforming white fat to brown fat may hold great potential in preventing or treating obesity and obesity-related metabolic disorders, since white fat is more easily reachable and manipulatable considering its abundance and location. Uncoupling protein 1 (UCP1) is uniquely expressed in brown adipocytes and facilitates fuel utilization and energy expenditure. Here, we utilized the CRISPR/Cas9 synergistic activation mediator and specific gRNAs to boost endogenous UCP1 expression in human white adipocytes. The CRISPR/Cas9 engineered human brown fat-like (HUMBLE) cells had acquired human brown fat features when comparing bona fide human brown adipocytes derived from the same individual. Obese mice that received HUMBLE cell transplants showed lower body weight, a sustained improvement in glucose tolerance and insulin sensitivity, as well as increased energy expenditure. Mechanistically, increased arginine/nitric oxide (NO) metabolism in HUMBLE adipocytes promoted the production of NO that was carried by S-nitrosothiols and nitrite in red blood cells to activate endogenous brown fat and improved glucose homeostasis in recipient animals. Taken together, these data demonstrate the utility of using CRISPR/Cas9 technology to engineer human white adipocytes to display brown fat-like phenotypes and may open up cell-based therapeutic opportunities to combat obesity and diabetes.

敬邀參加109年12月9日(W3) 轉譯學程專家演講 李岡遠 教授/雙和醫院研副院長

敬邀參加109年12月9日(W3) 轉譯學程專家演講
主講人:李岡遠 教授
講 題:From aberrant inflammation to repair and regeneration- An Evolutionary Perspective on COPD
時 間:109年12月9日(W3) 13:00~15:00
地 點:大安校區 B2 B203會議室
報名方式:
1.北醫教職員:
請先登入 http://goo.gl/p2qWP9
進入此頁面報名
2. 學生、無法登入學習發展平台者:請直接前往會場即可
誠摯邀請本校教師與同仁們撥冗參與!
專家演講.jpg
Special Lecture
 

Speaker: Prof. Kang-Yun Lee
Date :2020-12-9 (Wednesday)

Venue: B203, B2F, Daan campus

Time:13:00~15:00

Research Interests: 

Epigenetic regulation of inflammation in airway disease

Cancer Immunology

Tumor microenvironment

From aberrant inflammation to repair and regeneration
– An Evolutionary Perspective on COPD


COPD has great impact on human health, which is the fourth leading cause of death worldwide. It is believed that chronic inflammation is central to the pathogenesis of the disease, causing progressive and irreversible airflow limitation. The inflammation in the airways and the lung is chronic, amplified and self-perpetuated with poor response to glucocorticoids. Although large efforts have been made to develop anti-inflammatory medications, particularly kinases inhibitors, none of them has promising results. Other directions including the epigenetic, anti-oxidant, specific immune abnormality (e.g. Th-17, Tc1, ILC1…) are still struggling. In addition to inflammation, other pathogenetic mechanisms might also have implication, in particular repair and regeneration. We currently focus on air pollution-induced emphysema and has identified novel players in the pathogenesis of the disease, such as Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4). In this talk, the evolution of the concept of COPD pathogenesis will be reviewed, which will point to a new direction of treatment of COPD.

唐獎教育基金會舉辦唐獎第四屆大師論壇

唐獎教育基金會舉辦唐獎第四屆大師論壇生醫場之會議影片已上傳,提供影片連結如下。歡迎踴躍觀看!
 

【敬請踴躍參加】林百里董事長名譽博士頒授典禮暨專題演講

北醫將於9/17(四)10:00 舉辦林百里董事長名譽博士頒授典禮,且非常難得機會邀請廣達集團林百里董事長進行專題演講,特別懇請各單位師生參加典禮,對象以教師、研究生優先,教職員亦非常樂意歡迎您出席。
(認列教師繼續教育點數、職員教育訓練時數1小時)
教職員報名網址(需先登入教職員工學習發展系統):http://training.tmu.edu.tw/_service/omega/EnrollAdmin/CourseInfo.aspx?coursePK=3280&classPK=9235&enroll=true
【林百里董事長名譽博士頒授典禮暨專題演講】
時間:2020/09/17(四)10:00-11:30 (敬請提前09:50入座)
地點:本校醫學綜合大樓後棟16樓國際會議廳
活動流程資訊如下,敬請參閱:
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
廣達集團林百里董事長於1988年創立廣達電腦,目前已成為全球Fortune 500大公司之一,是全球筆記型電腦、雲端運算及其他科技產品專業設計製造領域的領導品牌,林董事長引領IT產業變革30年,近年更積極導入AI跨域,包括智慧醫療、智慧製造及智慧交通等。林董事長心心念念為台灣的科技業把脈,開創台灣科技產業轉型成功的商業模式,他的精神是青年學子的楷模與典範,本校將頒授崇高的名譽博士學位予林董事長。當天除頒贈儀式外,林百里董事長亦將進行專題演講,機會難得,敬邀北醫大體系教職員生踴躍報名參加!!

【敬邀參與 08/17 14:30】細胞治療與再生醫學論壇 八月特色團隊研究會議

●報名網址:
一校三院教職員工:教職員訓練發展系統  http://training.tmu.edu.tw/
學生/助理/校外人士:學術活動網 http://event.tmu.edu.tw/actnews/?Sn=3920
歡迎大家踴躍報名參加~

【敬邀參加】108學年度「提升研究創新能量」系列講座-109/08/13-中央研究院孫以瀚特聘研究員-「Glia-Neuron Interactions in the Fly Visual System: Development, Maintenance and Degeneration」(10:00-11:30 後棟八樓徐千田廳)

108學年度「提升研究創新能量」系列講座-109/08/13-中央研究院孫以瀚特聘研究員-「Glia-Neuron Interactions in the Fly Visual System: Development, Maintenance and Degeneration」(10:00-11:30 後棟八樓徐千田廳)