拇山生物醫學研究講座
| 主題：
Topic |
Chromatin remodeling genes in gynecologic cancer progression and therapy |
| 演講者：
Speaker |
施益民 教授 Ie-Ming Shih, M.D., Ph.D.
Richard W. TeLinde Distinguished Professor Director, TeLinde Gynecologic Disease Program Co-Director, Women’s Malignancies Program |
| 時間：
Date |
111年2月22日(二) 上午10:00~12:00
February 22, 2022, 10:00-12:00 |
| 地點：
Venue |
醫學綜合大樓前棟四樓誠樸廳 4F Hall, Comprehensive Medical Building (Front Building) |
| 語言：
Language |
中文 Chinese |
| 主辦單位：
Organizer |
醫學科學研究所 |
Abstract:
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of cancers, especially in those gynecologic cancers arising from ectopic or eutopic endometrium including ovarian clear cell, ovarian endometrioid and uterine endometrioid carcinomas. As a subunit of SWI/SNF chromatin remodeler, ARID1A facilitates target-specific binding of SWI/SNF complexes to chromatin, thereby altering the accessibility of chromatin to a variety of nuclear factors. In human cancer, ARID1A possesses not only features of a gatekeeper, regulating cell cycle progression, but also features of a caretaker, preventing genomic instability through DNA damage repair. Moreover, an increasing body of evidence suggests that ARID1A containing SWI/SNF complexes play a pivotal role in transcriptional regulation of genes involving in several cancer-associated signaling pathways. In this seminar, we will discuss the mechanisms underlying how ARID1A mutations cause cancer progression and the clinical implications of synthetic lethality in developing ARID1A mutation-based therapeutics.
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